Introduction: The phenomenon of immune paralysis of innate immune cells is well described in sepsis and poses a further challenge to the treatment of this condition. Recently also in acute-on-chronic liver failure (ACLF), sepsis-like immune paralysis of neutrophils and monocytes has been described. Sepsis is a major cause of decompensation of liver cirrhosis and mortality of a patient with sepsis and ACLF is extraordinary high. Therefore we aimed to compare neutrophil function of patients with sepsis and patients with ACLF to identify differences in the immune dysfunction of these two conditions. Methods: 8 patients with septic shock and 6 patients with ACLF were studied. Neutrophil function was assessed by FACS analysis using the Phagoburst and Phagotest kit. (Orpegen, Heidelberg). Neutrophil function, clinical and biochemical data were compared. Results: Patients with ACLF had significantly lower haemoglobin (p
INNATE IMMUNE DYSFUNCTION IN SEPSIS AND ACUTE- ON-CHRONIC LIVER FAILURE
Rybczynski, M. (Author). 2011
Student thesis: Diploma thesis