Impact of glycine on liver after chemotherapy with FOLFOX

Abstract

Hepatotoxic side effects of chemotherapy for colorectal liver metastases increase perioperative morbidity and mortality after liver resection. Glycine has been shown to possess hepatoprotective effects in various animal models. Thus, this study was designed to assess its effect on liver after chemotherapy. Female Sprague-Dawley rats (200 – 220 g) were divided into two groups and received a 5% glycine or a control diet for 5 days. Subsequently, FOLFOX (Oxaliplatin, Leucovorin, and fluorouracil) chemotherapy was administered at standard doses. Transaminases, histology, immunohistochemistry and in vivo microscopy were used to index hepatic injury, to monitor microperfusion, and activation of Kupffer cells. Analysis of variance (ANOVA) followed by ttest were used as appropriate. Results are presented as mean ± SEM. Glycine significantly decreased transaminases after chemotherapy to 25-50 % of control values (p

Date of Award	2009
Original language	English
Awarding Institution	Heidelberg University
Supervisor	Peter Schemmer (Supervisor)