Detection of heart failure during the ECG recording using the CombynTM ECG

Abstract

Objective: The objective of this thesis was to investigate the potential of detecting HF during routine-ECG using impedance plethysmography and impedance spectroscopy integrated into a 12-lead ECG by comparing the results with gold-standards e.g. serum NT-proBNP levels and the NYHA functional classification. Background: Despite our best efforts HF still represents a major cause of morbidity and mortality all around the globe. Its timely diagnosis and accurate grading is crucial for providing adequate medical therapy, improving quality of life and preventing chronification of disease. Material and methods: We obtained measurements of 827 individuals with the CombynTM ECG at the institute of cardiovascular medicine, Mariatrosterstraße 67 and the outpatient department of cardiology at the state hospital Graz. An electrocardiogram (ECG) was obtained and segmental impedance measurements were performed at 5, 40 and 400 kHz. Additionally, the patients were asked to grade their degree of functional impairment by using the NYHA classification and blood samples were drawn to measure serum NT-proBNP levels. All data were exported to Microsoft Excel and statistical analysis was performed using the statistical software program SPSS. Results: Comparison of serum NT-proBNP levels with Heart function (estimated degree of HF determined by the CombynTM ECG) showed a significant association between all the results (p

Date of Award	2023
Original language	English
Awarding Institution	Medical University Graz
Supervisor	Falko Skrabal (Supervisor) & Friedrich Fruhwald (Co-supervisor)