Correlations of prenatal Human Milk Oligosaccharides with maternal lipid profiles

Abstract

Introduction: Human milk oligosaccharides (HMOs) are complex, unconjugated glycans highly abundant in human milk and serve as prebiotics, antiadhesive antimicrobials and cell modulators. As “prenatal HMOs” they emerge in the mother’s blood already during pregnancy from the early second trimester on, suggesting systemic functions. Potential environmental factors that influence the highly individual HMO composition have not been investigated so far. For this thesis, correlations between prenatal HMOs and blood lipids (mirroring one aspect of the mothers’ “metabolic situation”) have been analyzed. Materials and Methods: Blood lipids (triglycerides, total cholesterol, LDL, HDL) and 17 prenatal HMOs (24th week of gestation, measured by NP-HPLC) were analyzed in serum samples taken from 94 Dutch women, followed by a calculation of Spearman rank correlations. Results: Within the subgroup of secretor-positive women relative concentrations of 3’SLN positively correlated with LDL (r=0.42, p

Date of Award	2019
Original language	English
Awarding Institution	Medical University Graz
Supervisor	Evelyn Jantscher-Krenn (Supervisor) & Mireille Nicoline Maria Van Poppel (Co-supervisor)