Background and Aim: The aim of this study was to investigate the influence of arterial blood pressure on cerebral tissue oxygen saturation index (cTOI) and cerebral fractional tissue oxygen extraction (cFTOE) in preterm and term neonates during the immediate neonatal transition after birth. Material and Methods: For this purpose, we conducted a prospective observational study. Preterm neonates with and without respiratory support and term neonates with and without respiratory support received oscillometric blood pressure measurements at minutes 5, 10, and 15 after birth, a continuous cTOI monitoring with near-infrared spectroscopy and a continuous monitoring of arterial oxygen saturation (SpO2) with pulse oximetry during the first 15 minutes after birth. cFTOE was calculated out of cTOI and SpO2. Afterwards cTOI and cFTOE at minutes 5, 10, and 15 were correlated to systolic (SABP), diastolic (DABP), and mean arterial blood pressure (MABP) in all groups. Results: This study included 102 preterm and term neonates with and without respiratory support. In the preterm neonates with respiratory support cTOI correlated positively with DABP at all time points and it also correlated with MABP at minute 15. CFTOE correlated negatively with all MABP and DABP values at all time points and it also correlated with the SABP at minute 5. In stable preterm neonates and term neonates with and without respiratory support blood pressure values did correlate neither with cTOI nor with cFTOE at any time point. Conclusion: In compromised preterm neonates requiring respiratory support, cerebral oxygenation (cTOI and cFTOE) was associated with the different parameters of blood pressure at all time points during the first 15 minutes after birth, whereas no such associations were observed in stable preterm neonates and term neonates with and without respiratory support.
Arterial blood pressure and cerebral tissue oxygenation during immediate transition after birth in term and preterm neonates – a prospective pilot observational study
Pfurtscheller, D. (Author). 2025
Student thesis: Doctoral thesis