Neural network emulation of the human ventricular cardiomyocyte action potential: A promising tool for more efficient computations in quantitative systems pharmacology studies

Thomas Grandits; Christoph M. Augustin; Gundolf Haase; Norbert Jos; Gary R. Mirams; Steven A. Niederer; Gernot Plank; Andras Varro; Laszlo Virag; Alexander Jung

doi:10.1016/j.vascn.2025.107850

Neural network emulation of the human ventricular cardiomyocyte action potential: A promising tool for more efficient computations in quantitative systems pharmacology studies

Thomas Grandits
, Christoph M. Augustin
, Gundolf Haase
, Norbert Jos
, Gary R. Mirams
, Steven A. Niederer
, Gernot Plank
, Andras Varro
, Laszlo Virag
, Alexander Jung

Division of Medical Physics and Biophysics

Research output: Contribution to journal › Conference abstract

Original language	English
Article number	107850
Number of pages	1
Journal	Journal of Pharmacological and Toxicological Methods
Volume	135
Early online date	Sept 2025
DOIs	https://doi.org/10.1016/j.vascn.2025.107850
Publication status	Published - Sept 2025
Event	2024 Safety Pharmacology Society Annual Meeting - San Diego, United States Duration: 22 Sept 2024 → 25 Sept 2024

Branches of science

102 Computer Sciences
103 Physics, Astronomy
206 Medical Engineering
301 Medical-Theoretical Sciences, Pharmacy
302 Clinical Medicine

DOI

10.1016/j.vascn.2025.107850

Links

Web of Science

Neural network emulation of the human ventricular cardiomyocyte action potential: A promising tool for more efficient computations in quantitative systems pharmacology studies
Grandits, T. (Speaker), Augustin, C. (Author), Haase, G. (Author), Jos, N. (Author), Mirams, G. (Author), Niederer, S. (Author), Plank, G. (Author), Varro, A. (Author), Virág, L. (Author) & Jung, A. (Author)
2025
Activity: Talk, presentation or poster › Poster

Cite this

Grandits, T., Augustin, C. M., Haase, G., Jos, N., Mirams, G. R., Niederer, S. A., Plank, G., Varro, A., Virag, L., & Jung, A. (2025). Neural network emulation of the human ventricular cardiomyocyte action potential: A promising tool for more efficient computations in quantitative systems pharmacology studies. Journal of Pharmacological and Toxicological Methods, 135, Article 107850. https://doi.org/10.1016/j.vascn.2025.107850

@article{aed0ddc7365442b0b7f304b9f1c50656,

title = "Neural network emulation of the human ventricular cardiomyocyte action potential: A promising tool for more efficient computations in quantitative systems pharmacology studies",

author = "Thomas Grandits and Augustin, \{Christoph M.\} and Gundolf Haase and Norbert Jos and Mirams, \{Gary R.\} and Niederer, \{Steven A.\} and Gernot Plank and Andras Varro and Laszlo Virag and Alexander Jung",

year = "2025",

month = sep,

doi = "10.1016/j.vascn.2025.107850",

language = "English",

volume = "135",

journal = "Journal of Pharmacological and Toxicological Methods",

issn = "1056-8719",

publisher = "Elsevier Inc.",

note = "2024 Safety Pharmacology Society Annual Meeting ; Conference date: 22-09-2024 Through 25-09-2024",

}

Grandits, T, Augustin, CM, Haase, G, Jos, N, Mirams, GR, Niederer, SA, Plank, G, Varro, A, Virag, L & Jung, A 2025, 'Neural network emulation of the human ventricular cardiomyocyte action potential: A promising tool for more efficient computations in quantitative systems pharmacology studies', Journal of Pharmacological and Toxicological Methods, vol. 135, 107850. https://doi.org/10.1016/j.vascn.2025.107850

Neural network emulation of the human ventricular cardiomyocyte action potential: A promising tool for more efficient computations in quantitative systems pharmacology studies. / Grandits, Thomas; Augustin, Christoph M.; Haase, Gundolf et al.
In: Journal of Pharmacological and Toxicological Methods, Vol. 135, 107850, 09.2025.

Research output: Contribution to journal › Conference abstract

TY - JOUR

T1 - Neural network emulation of the human ventricular cardiomyocyte action potential

T2 - 2024 Safety Pharmacology Society Annual Meeting

AU - Grandits, Thomas

AU - Augustin, Christoph M.

AU - Haase, Gundolf

AU - Jos, Norbert

AU - Mirams, Gary R.

AU - Niederer, Steven A.

AU - Plank, Gernot

AU - Varro, Andras

AU - Virag, Laszlo

AU - Jung, Alexander

PY - 2025/9

Y1 - 2025/9

UR - https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=medunigraz_woslite&SrcAuth=WosAPI&KeyUT=WOS:001602612900075&DestLinkType=FullRecord&DestApp=WOS_CPL

U2 - 10.1016/j.vascn.2025.107850

DO - 10.1016/j.vascn.2025.107850

M3 - Conference abstract

SN - 1056-8719

VL - 135

JO - Journal of Pharmacological and Toxicological Methods

JF - Journal of Pharmacological and Toxicological Methods

M1 - 107850

Y2 - 22 September 2024 through 25 September 2024

ER -

Grandits T, Augustin CM, Haase G, Jos N, Mirams GR, Niederer SA et al. Neural network emulation of the human ventricular cardiomyocyte action potential: A promising tool for more efficient computations in quantitative systems pharmacology studies. Journal of Pharmacological and Toxicological Methods. 2025 Sept;135:107850. Epub 2025 Sept. doi: 10.1016/j.vascn.2025.107850

Neural network emulation of the human ventricular cardiomyocyte action potential: A promising tool for more efficient computations in quantitative systems pharmacology studies

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DOI

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Neural network emulation of the human ventricular cardiomyocyte action potential: A promising tool for more efficient computations in quantitative systems pharmacology studies

Cite this