Introduction: Women with polycystic ovary syndrome (PCOS) frequently suffer from metabolic disturbances, in particular from insulin resistance. Accumulating evidence suggests that vitamin D deficiency may contribute to the development of insulin resistance. The association of vitamin D with endocrine, metabolic, and genetic aspects in PCOS is largely unknown. Methods: We performed a cross-sectional study including 206 PCOS women to investigate the association of serum 25-hydroxyvitamin D (25[OH]D) levels with metabolic and endocrine parameters. Moreover, we carried out an intervention study including 57 PCOS women, who received 20.000 IU cholecalciferol weekly for 24 weeks. Further, genotyping of vitamin D receptor (VDR) (Cdx-2, Bsm-I, Fok-I, Apa-I, and Taq-I), GC, DHCR7, and CYP2R1 polymorphisms was performed in 545 PCOS and 145 control women Results: We found a significantly negative correlation between 25(OH)D levels and BMI, weight, waist circumference, hip circumference, WHR, blood pressure, fasting and stimulated glucose, AUCglucose, fasting insulin, homeostatic model assessment-insulin resistance (HOMA-IR), HOMA-β, triglycerides, and QChol/HDL and a positive correlation with Quantitative Insulin-sensitivity Check Index (QUCKI) and HDL (p
The Role of Vitamin D in Polycystic Ovary Syndrome-Metabolic, Endocrine and Genetic Aspects
Lerchbaum, E. (Autor/-in). 2011
Studienabschlussarbeit: Dissertation