MiR-96-5p level influences cellular growth and survival in colorectal cancer

Abstract

Background: Expression of miR-96-5p is frequently altered in various types of cancer. However, the biological role of miR-96-5p expression in colorectal cancer (CRC) cells and its ability to predict the clinical course of patients has not been investigated yet. Methods: We explored miR-96-5p expression in 80 CRC patients and evaluated the impact on clinical outcome. In vitro miR-96-5p expression manipulation was performed in CRC cells and the effects on cellular growth, apoptosis and epithelial-mesenchymal transition (EMT)-related gene expression were explored. Results: Multivariate Cox regression analysis identified low levels of miR-96-5p as independent prognostic factors with respect to cancer-specific survival (hazard ratio=1.8, 95%CI=1.04-3.1, p

Datum der Bewilligung	2016
Originalsprache	Englisch
Gradverleihende Hochschule	Medizinische Universität Graz
Betreuer/-in	Martin Pichler (Betreuer*in) & Thomas Bauernhofer (Mitbetreuer*in)