Local recurrence after resection of soft tissue sarcomas: a multifactorial analysis.

Abstract

Background. Patients with soft tissue sarcoma (STS) being treated following the standardized guidelines, i.e. resection and adjuvant radiation therapy for selected patients, can still not be guaranteed to remain free from local recurrence (LR) of the sarcoma at resection site. This study was designed to analyse various characteristics of patients and tumors and their potential impact on local recurrence. Methods. This retrospective study included 374 patients, who were diagnosed with STS and underwent resection between 1998 and 2013. Analyses included histological reports, surgery reports and follow up for recurrence and survival of each patient with focus on the factors resection margin, grading, size, depth of the tumor and age and gender of the patient. Two different classifications were applied for the factor resection margin. Applied statistical methods were the Kaplan-Meier survival curve analysis, Log rank test, Cox proportional hazards model and cross tabulations with chi-square test. For statistical analyses SPSS 22 was used. Results. In univariate cox regression analysis the significant factors for local recurrence resulted to be age (HR 4,19 for ≥50 years, 95%CI=1,28–13,74, p=0,018) and resection margin for two different classifications (R-classification: HR 5,62 for R1, 95%CI=2,67–11,84, p

Datum der Bewilligung	2015
Originalsprache	Englisch
Gradverleihende Hochschule	Medizinische Universität Graz
Betreuer/-in	Andreas Leithner (Betreuer*in) & Joanna Szkandera (Mitbetreuer*in)