Until today the causes and triggers of sarcoidisis are not identified. Subject of this study was to analyse genes of the proliferation-pathway via PI3K and Akt. This investigation was bases on the consideration that enhanced proliferation might be responsible for the presence of immunocompetent cells in sarcoidosis. Using real-time PCR, we were able to find out that genes of this pathway are not overexpressed, except of one catalytic subunit of PI3K. Therefore we assumed that there is a proliferation stimulus primary aiming onto another pathway. Additionally, we found evidence that apoptosis is inhibited.
Cell proliferation analysis in sacoidosis lavage cells
Markert, E. (Autor/-in). 2005
Studienabschlussarbeit: Dissertation