Nonclinical evaluation of APL-4098, a novel GCN2 kinase inhibitor, reveals potent anti-leukemic effects through mitochondrial stress induction and synergy with venetoclax, targeting AML blasts and LSCs

M Roman-Trufero; K Blighe; Armin Zebisch; Bianca Perfler; SA Herzog; R Butt; H Auner; N Clemo

doi:10.1182/blood-2025-1503

Nonclinical evaluation of APL-4098, a novel GCN2 kinase inhibitor, reveals potent anti-leukemic effects through mitochondrial stress induction and synergy with venetoclax, targeting AML blasts and LSCs

M Roman-Trufero
, K Blighe
, Armin Zebisch
, Bianca Perfler
, SA Herzog
, R Butt
, H Auner
, N Clemo

Publikation: Beitrag in Fachzeitschrift › Konferenzabstract

Originalsprache	Englisch
Fachzeitschrift	Blood
DOIs	https://doi.org/10.1182/blood-2025-1503
Publikationsstatus	Veröffentlicht - 2025
Veranstaltung	67th Annual Meeting of the American-Society-of-Hematology (ASH) - Orlando, USA/Vereinigte Staaten Dauer: 6 Dez. 2025 → 9 Dez. 2025

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305 Andere Humanmedizin, Gesundheitswissenschaften

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10.1182/blood-2025-1503

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Nonclinical evaluation of APL-4098, a novel GCN2 kinase inhibitor, reveals potent anti-leukemic effects through mitochondrial stress induction and synergy with venetoclax, targeting AML blasts and LSCs
Roman-Trufero, M. (Autor*in), Blighe, K. (Autor*in), Zebisch, A. (Autor*in), Perfler, B. (Autor*in), Herzog, S. (Autor*in), Butt, R. (Autor*in), Auner, H. (Autor*in) & Clemo, N. (Autor*in)
2025
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@article{fa6825c702d345f98ddb1017bea5b945,

title = "Nonclinical evaluation of APL-4098, a novel GCN2 kinase inhibitor, reveals potent anti-leukemic effects through mitochondrial stress induction and synergy with venetoclax, targeting AML blasts and LSCs",

author = "M Roman-Trufero and K Blighe and Armin Zebisch and Bianca Perfler and SA Herzog and R Butt and H Auner and N Clemo",

year = "2025",

doi = "10.1182/blood-2025-1503",

language = "English",

journal = "Blood",

issn = "0006-4971",

publisher = "Elsevier B.V.",

note = "67th Annual Meeting of the American-Society-of-Hematology (ASH) ; Conference date: 06-12-2025 Through 09-12-2025",

}

TY - JOUR

T1 - Nonclinical evaluation of APL-4098, a novel GCN2 kinase inhibitor, reveals potent anti-leukemic effects through mitochondrial stress induction and synergy with venetoclax, targeting AML blasts and LSCs

AU - Roman-Trufero, M

AU - Blighe, K

AU - Zebisch, Armin

AU - Perfler, Bianca

AU - Herzog, SA

AU - Butt, R

AU - Auner, H

AU - Clemo, N

PY - 2025

Y1 - 2025

UR - https://www.webofscience.com/wos/woscc/full-record/WOS:1658801900004

U2 - 10.1182/blood-2025-1503

DO - 10.1182/blood-2025-1503

M3 - Conference abstract

SN - 0006-4971

JO - Blood

JF - Blood

T2 - 67th Annual Meeting of the American-Society-of-Hematology (ASH)

Y2 - 6 December 2025 through 9 December 2025

ER -

Nonclinical evaluation of APL-4098, a novel GCN2 kinase inhibitor, reveals potent anti-leukemic effects through mitochondrial stress induction and synergy with venetoclax, targeting AML blasts and LSCs

Wissenschaftszweige

Zugriff auf Dokument

Andere Dateien und Links

Aktivitäten

Nonclinical evaluation of APL-4098, a novel GCN2 kinase inhibitor, reveals potent anti-leukemic effects through mitochondrial stress induction and synergy with venetoclax, targeting AML blasts and LSCs

Dieses zitieren